ADAR and cancer: Accumulated evidence suggests that adenosine deaminase acting on RNA (ADAR) enzymes, such as ADAR1 and ADAR2, accelerates tumour development.12, 13 The ADAR enzyme is a double‐stranded RNA (dsRNA) binding protein that regulates adenosine into inosine (A to I) at the post‐transcriptional level.14 ADAR2, an indispensable enzyme for brain development and function,15 is enough to inhibit glioblastoma proliferation or cancer progress.16 Then, we speculated that ADAR2 could be associated with the development of the enteric nervous system (ENS).