In term of studies regarding the 14‐3‐3σ isoform in kidneys, not much is known, except for its involvement in renal cell carcinoma; cell culture studies demonstrated that when a specific mutant Von Hippel‐Lindau protein is expressed, 14‐3‐3σ is down‐regulated.36 However, no other studies exist on the role of 14‐3‐3σ in other pathological processes in the kidney, like renal fibrosis. This evidence concerns the gene YWHAQ and renal cell carcinoma.