TP53 and urinary bladder cancer: One of the bladder cancer risk SNPs, rs710521 (A > G variant, A is risk-increasing allele) is located in an intergenic region between TP63 and LEPREL1 on chromosome 3q28, in a linkage disequilibrium (LD) block encompassing the TP63 gene [2], which codes for a member of the p53 family of transcription factors.