Until now, 14 bladder cancer risk loci, including TP63, c-MYC [2], TERT/CLPTM1L [3], FGFR3/TACC3 [4], PSCA [5], APOBEC3A/CBX6, CCNE1, UGT1A [6], SLC14A1 [7, 8], JAG1 [9, 10], TERC, LSP1 [10] and MCF2L [11] have been described. The gene discussed is CCNE1; the disease is urinary bladder carcinoma.