Shmt1+/−ApcMin/+ mice fed FD diets have increased total intestinal tumors and increased uracil in colon DNA relative to Shmt1+/+ApcMin/+ mice, suggesting a relation between Shmt1 heterozygosity, folate status, uracil in DNA, and intestinal tumorigenesis (13). This evidence concerns the gene SHMT1 and intestinal neoplasm.