TGFB1 and Hepatic fibrosis: The signaling mechanism suggested to explain that the activation of HSCs is associated with FC accumulation, which sensitizes the cells to TGF-β through TLR4 upregulation and downregulation of the TGF-β pseudoreceptor BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor), leading to TGF-β-induced liver fibrosis [109].