In the report, it was suggested that HIF-1α may regulate tumor growth by regulating ectoenzyme, ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), and extracellular levels of 5′-AMP to promote tumor growth through shaping the microenvironment of the HCC tumor in addition to direct impact. This evidence concerns the gene ENTPD2 and neoplasm.