Vascular Endothelial Growth Factor (VEGF) is a key angiogenetic cytokine that regulates cell mitosis and endothelial cells permeability.34 Overexpression of VEGF has been found to correlate with cancer relapse and decreased survival in patients affected by different solid tumours, including OC.35 Despite previous studies, absence of significant changes in MVD and VEGF profile following disease progression of this unique cohort, indicates that these markers are not major drivers of molecular cancer evolution in vivo, but rather remain supportive factors. This evidence concerns the gene VEGFA and cancer.