RSPO1 and colorectal carcinoma: Several studies identified various fusion genes in CRC, including NAV2-TCF7L1, RSPO, BRAF, NTRK3, RET, and RAS fusion genes, as good candidates of molecularly targeted therapy.4, 7, 8 Our strict filtering approach uncovered novel fusion genes in CRC, compared to fusion gene databases, such as Tumour Fusion Gene Data Portal20 and Catalogue of Somatic Mutations in Cancer (COSMIC), and other studies.