POLE and colorectal carcinoma: Interestingly, it had three mutations in the DNA polymerase epsilon catalytic subunit (POLE) gene (NM_006231: exon39: c.5239G>A: p.D1747N, exon35: c.4522C>T: p.R1508C, and exon14: c.1376C>T: p.S459F), which was previously reported as a driver of hypermutated CRC,4 while the other patients did not have a POLE mutation or had only one POLE mutation.