The Sca1-Dnmt1 mice that developed myeloid malignancies showed marked expansion of Mac1+Gr1+ granulocytes in the blood and bone marrow (Fig. 2c and S3), as well as the presence of an abnormal myeloid population (Mac1+Gr1low) in the bone marrow (Fig. 2c). Here, DNMT1 is linked to myeloid neoplasm.