MAPK8 and columnar cell hyperplasia of the breast: Similar to 3-MA, SP600125 significantly increased the protein expression of p62 and decreased the protein expression of beclin-1 and the LC3-II to LC3-I ratio relative to BCCAo rats (Fig.6), confirming that the non-nuclear JNK pathway may be involved in the process of CCH-induced abnormal excessive autophagy.