These results are important to better understand the involvement of heparanase and rs4693608 SNP in acute inflammation, acute and extensive chronic GVHD, risk of sinusoid obstruction syndrome/VOD following allogeneic stem cell transplantation, and symptomatic carotid atherosclerosis (Fig. 9)20–23. The gene discussed is HPSE; the disease is carotid atherosclerosis.