Being at WHO clinical stage 3 (AOR = 5.82; 95% CI 1.04–32.30), not taking INH prophylaxis (AOR = 12.36; 95% CI 4.47–34.14), CD4 level of < 200 cells/mm3 (AOR = 7.34; 95% CI 2.75–19.58) and a CD4 level of 200–500 cells/mm3 (AOR = 4.85; 95% CI 1.95–12.05) at ART initiation were significant determinants of increased risk of TB co-infection among PLWHAs (Table 2). The gene discussed is CD4; the disease is tuberculosis.