TNF and glioblastoma: GO analysis of genes upregulated in adult GBM-associated macrophages compared to DIPG-associated macrophages included the terms inflammatory response, positive regulation of smooth muscle cell proliferation, cellular response to interleukin-1, positive regulation of transcription from RNA polymerase II promoter, immune response, cellular response to tumor necrosis factor, and chemokine-mediated signaling pathway (Table 2).