SVIL and hepatocellular carcinoma: To determine the potential role of supervillin, especially the different supervillin splicing isoforms on HCC cell migration and invasion under hypoxic conditions, we used Stealth RNAiTM dsRNAs that target sequences within SVIL coding exon 4 (RNAi #1; specific for SV4), coding exon 5 (RNAi #2; targets both SV4 and SV5), coding exon 10 (RNAi #3; targets all three isoforms), and the 3’-UTR (RNAi #4; targets all three isoforms).