SVIL and hepatocellular carcinoma: Supervillin knockdown with RNAi #2 or #3 resulted in a 65 and 72% reduction in cell migration (Fig. 2e and g, and Additional file 1: Figure S2C and D) and a 73 and 59% reduction in cell invasion (Fig. 2f and h, and Additional file 1: Figure S2E and F) for Huh-7 and MHCC-97H cells after 18 h in normoxia, respectively, and almost completely abolished hypoxia-induced increases in HCC cell migration and invasion.