For the first time, our data show that by inducing growth inhibition and apoptosis, combination of the PARP inhibitor olaparib with the WEE1/PLK1 dual inhibitor AZD1775 exerted evidently enhanced antitumor effects in GC cell lines and xenografts than either olaparib or AZD1775 alone (Figs. 1, 2 and 5). Here, PLK1 is linked to gastric cancer.