Monotherapy of either olaparib or AZD1775 reduced GC cell growth (Fig. 1b and c), while the combination of olaparib and AZD1775 intriguingly exerted higher growth inhibition than single-agent groups (Fig. 1d), indicating an augmented antitumor effect of PARP inhibitor in the presence of WEE1/PLK1 dual blockade against GC cells. The gene discussed is PARP1; the disease is gastric cancer.