Of these 55 proteins, 11 (including App, Apoe, Htra1, Cotl1 and Clu) were concordantly increased while 23 (including Vgf, Rtn4, Alpl, Scn3a and Camk4) were concordantly decreased in both 5xFAD microglia and human AD brain (Fig. 6a). This evidence concerns the gene RTN4 and Alzheimer disease.