Since Cotl1 stabilizes and promotes the activity of lipoxygenase 5 (5-LOX) to convert arachidonic acid to LT-A4 [30, 31], a co-upregulation of Lt4ah in AD microglia is predicted to facilitate LT-A4 conversion to LT-B4, a pro-inflammatory leukotriene implicated in neurotoxicity and Aβ formation [42–44]. This evidence concerns the gene COTL1 and Alzheimer disease.