Several proteins were differentially expressed in only in 5xFAD mouse microglia without any LPS-induced changes, including increased levels of App (Aβ peptide), Nop56, Ptn, Tmem151b and Mgrn1 and decreased levels of Hist2h2be, Sar1a, Ttc9a and Aimp3 (Fig. 4c), suggesting that these proteins may be uniquely relevant to AD pathology. This evidence concerns the gene TTC9 and Alzheimer disease.