BIRC2 and rhabdomyosarcoma: In rhabdomyosarcoma tissues and cell lines, IGF2BP1 was found to be overexpressed and drive the expression of cIAP1 that is a key modulator of apoptosis and contributes to tumor cell survival through controlling the nuclear factor-κB signalling and extrinsic cell death pathways, as well as promote disease progression and chemo-resistance by increasing IRES-mediated translation of cIAP1 [77, 78].