KRAS and malignant colon neoplasm: In the study, IGF2BP1 was established to promote colon cancer cell survival and regulate K-Ras expression via targeting 3′-UTR of K-Ras mRNA that frequently mutates in human cancers and regulates distinct cellular pathways important for the growth, differentiation, and survival of cell [68], in part by suppressing CYFIP2, which is a p53-inducible gene and may depress cell proliferation and caspase activation, and induce apoptosis in colon cancer [69].