However, their overexpression was observed to repress the cell proliferation and migration, and invasion of GBM through downregulating the IGF2BP1 levels, which reduces the level of c-MYC, CD44, MKI67, and PTEN mRNA in GBM cells or blocks G1/S transition in glioblastoma cell [44, 83]. This evidence concerns the gene CD44 and glioblastoma.