Another potential prognostic marker for HCC, miR-9, was observed to promote HCC cell proliferation and migration by hypermethylation-mediated downregulation of it and inhibit HCC development via suppressing AKT and ERK phosphorylation that are well known for their oncogenic properties after targeting IGF2BP1 [43]. This evidence concerns the gene IGF2BP1 and hepatocellular carcinoma.