IGF2BP1 and breast carcinoma: Additionally, IGF2BP1 was demonstrated to sustain tumor cell survival upon binding eIF5A and suppressing eIF5A-mediated apoptotic effects that depends on the cytoplasmic IGF2BP1 levels in ovarian and breast cancer of mouse [62], indicating their important role in the therapeutic trials using inhibitors of exportin1 (XPO1) that is the key nuclear export protein and essential for transporting cargo proteins with leucine-rich nuclear export sequences from the nucleus to the cytoplasm, such as leptomycin B [62, 63].