IGF2BP1 loss was found to inhibit the expression of K-Ras and Cdc34, the let-7 repressor Lin-28B, and c-Myc, concomitantly depress anchorage-independent growth and colon cancer cell proliferation, and trigger caspase-mediated cell death [67]. This evidence concerns the gene IGF2BP1 and malignant colon neoplasm.