Thus, bearing in mind the described limitation of post-transcriptional modulation of gene expression mediated by RNA-binding proteins (RBPs), miRNAs, and lncRNAs in determining fate of tumorigenesis, we in the following review recent findings on the expression of IGF2BP1 in cancers and focus on the interconnectivity of IGF2BP1 with its targeted mRNAs or ncRNAs. Here, IGF2BP1 is linked to cancer.