IGF2BP1 and neoplasm: However, in another observation of metastatic human breast tumor-driving cell and xenograft mouse model, the gain expression of IGF2BP1 inhibited tumor growth and metastases, which may be through the function of the KH3/4 domain of IGF2BP1 on its targeted mRNAs [17], suggesting other tumor-related inhibition paths for IGF2BP1 exist in addition to methylation-induced effects.