The real advantage of a CLS compared to last-generation SAPs with LGS and PLGS functions is the gradual modulation of basal insulin infusion in response to glycaemic variations (towards both hyperglycaemia and hypoglycaemia), which has the aim of improving the proportion of time spent in the target glucose range and reducing the mean glucose level without increasing the risk of hypoglycaemia. This evidence concerns the gene INS and Hyperglycemia.