This is not an easy point to address because in the present report we are finding alterations in HSP genes that are little known to be linked with breast cancer; moreover others like DNAJB3 (increased in HER2 subtype), DNAJB13 and DNAJC22 (increased in Luminal and Basal subtypes), and SACS (increased in all subtypes) have not been related with any cancer type. This evidence concerns the gene SACS and breast cancer.