NOTCH1 and metabolic syndrome: The angiogenic potency of MSC-derived EVs, which carry protein-encoding mRNAs that stimulate vascular development (e.g. VEGF-A, VEGF-C, VEGF receptors, etc.)and proteins (e.g. VEGF, Angiopoietin Like 4, Hepatocyte Growth Factor, etc.), might have contributed to the improved renal microvasculature, as renal expression of the pro-angiogenic proteins VEGF, Notch-1, and DLL4 improved in MetS+RVD+EVs.