Prior to this study, there were no previous studies on the relative levels of Ang-1, Ang-2, and VEGF in SCD patients with a haemolytic clinical sub-phenotype, including leg ulcers and priapism, in Ghana, where 2% of all births in Ghana are born with SCD or Sub-Saharan Africa, although reports indicate that angiogenic progenitors increase in VEGF in homozygous (HbSS) patients [6,23,26]. This evidence concerns the gene VEGFA and Priapism.