For the ALL data, take neurotrophin signaling pathway as example and consider one of the two significant NF-κB-ending cascades, i.e., 4916 → 53358 → 2549 → 5291 → 207 → 4792 → 4790 (Entrez IDs), as shown in Figure 6A. Figure 6C compares the principal patterns of the cascade between the two ALL classes, BCR and NEG. Here, NFKB1 is linked to acute lymphoblastic leukemia.