BDNF and acute lymphoblastic leukemia: For the ALL data, take neurotrophin signaling pathway as example and consider one of the two significant NF-κB-ending cascades, i.e., 4916 → 53358 → 2549 → 5291 → 207 → 4792 → 4790 (Entrez IDs), as shown in Figure 6A. Figure 6C compares the principal patterns of the cascade between the two ALL classes, BCR and NEG.