CASP3 and hepatitis B virus infection: Figure 6B,D shows the result for one of three-link chain in differentially expressed hepatitis B pathway: 5295 → 208 → 572 → 863 (Entrez IDs), which is involved in the activation cascade of caspases responsible for apoptosis execution. From Figure 6B,D, it can be seen that the principal pattern in NREC, D → N → N → U, leads to overexpression of CASP3 (Entrez ID: 863), and finally, activates the apoptosis of cell.