Moreover, PPARγ plays important roles in glucose metabolism by regulating the expression of hexokinase 2 (HK2) and the M2 isoform of pyruvate kinase (PKM2), resulting in massive liver steatosis in phosphatase and tensin homologs deleted on chromosome 10 (PTEN)-null mice [112]. The gene discussed is HK2; the disease is Hepatic steatosis.