PTGS2 and liver disorder: GrTPs downregulate IκB kinase (IKK), c-Jun N-terminal kinase-mitogen-activated protein kinase (JNK-MAPK) [81], nuclear factor-Kappa B (NF-kB), cytokine-like tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (Cox-2), and B-cell lymphoma (Bcl-2), to protect against hepatic disorders and numerous chronic and inflammatory disorders [82,83].