Regarding the association with CVD, type I IFNs present in SLE are considered to have a detrimental impact on the vasculature that promotes atherosclerosis, and this is done by upregulation of NLRP3, caspase-1, and IL-18 in endothelial progenitor cells [165]. The gene discussed is CASP1; the disease is systemic lupus erythematosus.