In mouse vascular endothelium, depletion of epsin-1 and -2 inhibits tumor growth by impairing the endocytosis and degradation of vascular endothelial growth factor receptor 2 (VEGFR2), leading to excessive VEGF signaling and results in disorganized vasculature and nonproductive tumor angiogenesis [62]. This evidence concerns the gene EPN1 and neoplasm.