Expression of TGM-3wascytoplasmic and nuclear staining expressed in keratinized layer, stratum granulosum and stratum spinosum in controls “Fig 1A” and also cytoplasmic and nuclear staining in tumour cells as shown in “Fig 1B, 1C and 1D.” In OSCC cases 76.70% cases were positive and in controls 90.62% cases were positive for TGM-3 IHC and the difference was statistically significant (p< 0.011) as shown in “Table 1”. This evidence concerns the gene TGM3 and neoplasm.