Overall survival was significantly associated with expression of TGM-3 (p<0.024) and response to chemo-radiotherapy treatment (p<0.000) as shown in “Fig 2D and 2E.” Other factors viz age, sex, tumour stage, differentiation, lymph node metastasis and adverse oral habit did not have statistical significant correlation with overall survival. This evidence concerns the gene TGM3 and neoplasm.