A total of 339 of those patients were excluded from this study: 128 had a hepatitis B virus (HBV) co-infection, 40 had a history of alcoholism, 6 had an HIV co-infection, 102 had received prior interferon therapy, 32 had a history of HCC, and 31 had missing AST, alanine-aminotransferase (ALT), or platelet count data within the 3 months prior to liver biopsy. The gene discussed is GPT; the disease is hepatocellular carcinoma.