Recent studies have identified two tumor suppressor genes, Zinc finger homeobox protein-3 (ZFHX3) and esophageal cancer related gene-4 (ECRG4), are closely related to the pathogenesis of AF.[21] Alteration in the expression of ZFHX3 has been reported in colon cancer[22], which also links to AF in our results. Here, ECRG4 is linked to malignant colon neoplasm.