NFKB1 and obesity due to melanocortin 4 receptor deficiency: The cause of β-cell inflammation in type 2 diabetes is debated, but likely relates to obesity as it is widely accepted that elevated nutrient levels stimulate the expression of interleukin-1β (IL-1β) in human pancreatic islets, via activation of the NLRP3 inflammasome [8–10] or the NF-κB pathway [11], which causes a pro-inflammatory state [12].