Proteolysis of MALT1 along with cleavage of BCL10 and RelB was detected in the ABC-DLBCL cell lines HBL-1, OCI-Ly3, but not in the GCB-DLBCL cell lines BJAB, SUDHL-4 and SUDHL-6 (Fig 3F). The gene discussed is MALT1; the disease is diffuse large B-cell lymphoma.