For this purpose, we analysed the stroma of DMBA/TPA-induced papillomas (n = 14 control, n = 2 Loxl2-KO, n = 10 Loxl2-KI) and squamous cell carcinomas (SCC) (n = 4 control, n = 2 Loxl2-KO, n = 1 Loxl2-KI) by H&E, Herovici and Picrosirius Red staining (Fig 6A–6C). Here, LOXL2 is linked to papilloma.