PEG3 and neoplasm: For example, PEG3, which had a p9 missense mutation in three UCEC tumors and one COAD/READ tumor and an H11Y mutation in one SKCM tumor, has been implicated in the tumor necrosis factor response pathway as part of a protein complex that activates NFκB [35]; it also plays a critical role in p53-mediated apoptosis [36].