However, they are entirely different diseases with different immunological backgrounds, research indicated that the incidence of anti-Ro and anti-La reactivity is infrequently found in patients with IgG4-related sialadenitis,[28] and their salivary glands are infiltrated by a large number of IgG4+ plasma cells and IgG4-related sialadenitis symptoms respond promptly to steroids. The gene discussed is CALR; the disease is sialadenitis.