Patients who developed SPC needs were also younger (P = 0.041) and had a more frequent history of myocardial infarction (P = 0.004) and diabetes (P = 0.029), but did not have more total co‐morbidity overall and did not have a significantly higher BNP or lower estimated glomerular filtration rate (eGFR) or haemoglobin (but did have a lower systolic blood pressure, P = 0.018). This evidence concerns the gene NPPB and myocardial infarction.