Remarkably, G403R in CaV1.3 (corresponding to position G432 in CaV1.2) [84], A749G in CaV1.3 (corresponding to position A780 in CaV1.2) [77], as well as G369D in CaV1.4 (corresponding to position G432 in CaV1.2) [48] all cause channelopathies, highlighting the key role of these residues in channel gating of different CaV families (see Table 1). The gene discussed is CACNA1C; the disease is channelopathy.