Moreover, Th17 lymphocytes are also directly involved in the course of various autoimmune diseases; nevertheless a certain mechanism of their action differs (Murdaca et al. 2011; Pesce et al. 2013; Singh et al. 2013; Vargas-Lowy et al. 2012)..The aim of this research was to describe the percentages and absolute counts of Th17, Treg, as well as activated T CD3+ and B CD19+ lymphocytes in patients with newly diagnosed PBC and to assess the relationships between analyzed cell subsets and selected clinical parameters (presence of itching and the degree of PBC severity). This evidence concerns the gene CD19 and primary biliary cholangitis.