By means of this fact, the deprivation of TGF-β signaling restricted to T cells might be the reason of pathological appearance of PBC (Bernuzzi et al. 2010; Fenoglio et al. 2012; Huang et al. 2014; Wang et al. 2015; Zhang et al. 2013; Yang et al. 2008). This evidence concerns the gene TGFB1 and primary biliary cholangitis.