AQP4 and neuromyelitis optica: As shown in Figure 2, and Table 1, all 5 experimental groups EAMG, NMO-Ig, AQP4 peptide, EAMG plus NMO-Ig, and EAMG plus AQP4 peptide (except the control CFA) showed significant reduction in the force values of 21.1–30.4% and increased fatigability compared to CFA (P < 0.05).