AQP4 and neuromyelitis optica: Significantly increased IL-6 secretion (compared to CFA-injected mice) was detected (Figure 4(b)), in EAMG control mice, in EAMG mice injected with NMO-Ig, and in naive mice injected with AQP4 peptide (1521 ± 59, 1004 ± 17.4 1303.7 ± 54, resp., and 560 ± 106.5 in the CFA-injected mice, P < 0.05).