Notably, miR125a-5p and miR-125b are upstream regulators of oncogenic sirtuin 7 (SIRT7), which is always overexpressed in HCC, and loss of SIRT7 induced p21WAF1/Cip suppresses cycle D1 expression, thus increasing the G1/S stage as well as suppressing proliferation [21]. The gene discussed is SIRT7; the disease is hepatocellular carcinoma.