Koopmans et al. used both lesion-based and patient-based analysis to confirm that MTC lesions are best detectable when serum calcitonin is >500 ng/L and 18F-DOPA PET is superior to 18F-FDG PET, DMSA-V, and morphologic imaging, whereas with short calcitonin doubling times (< or = 12 months), 18F-FDG PET may be superior [65]. The gene discussed is CALCA; the disease is medullary thyroid gland carcinoma.