The human Sod1 homolog has been identified as the first and major causative gene for autosomal dominant familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder, and some sporadic ALS patients (~3%) also possess mutations in the SOD1 gene (Chen et al., 2013; Saccon et al., 2013). Here, SOD1 is linked to amyotrophic lateral sclerosis.