Promoter regions of ENPP2 were found hyper-methylated in primary invasive breast carcinomas (13), while inhibition of histone deacetylases 3 and 7 with trichostatin A also attenuated ENPP2 expression in colon cancer cells (14), suggesting that ENPP2 expression can be also amenable to epigenetic regulation. This evidence concerns the gene ENPP2 and invasive breast carcinoma.