Subsegmental allergic challenge of asthma patients induced ATX/LPA levels in their BALFs (127, 128), while pharmacologic inhibition of ATX resulted in a marked attenuation of Th2 cytokines and allergic lung inflammation in a triple-allergen mouse asthma model (128); conflicting reports have suggested both pro-inflammatory and anti-inflammatory roles for LPAR2 (128–130). The gene discussed is ENPP2; the disease is asthma.