Inflammation can also increase IFNγ levels, which increases angiopoietin 2 (Ang2), matrix metalloproteinase 9 (MMP9), interferon γ-inducible 10-kDa proteins 9 (IP-9) and 10 (IP-10), all of which are downstream targets of IFN-γ, and could be potentially interpreted as markers for the development of BPD and ROP (50). The gene discussed is ANGPT2; the disease is bronchopulmonary dysplasia.