Of interest, these in vitro results are consistent with the in vivo observations that patients with castration-resistant prostate cancer exhibit a significantly decreased surface expression of NKG2D on circulating NK and CD8+ T cells and that cancer-derived exosomes extracted from plasma or serum of these patients induced NKG2D downregulation in cultured lymphocytes (108). The gene discussed is CD8A; the disease is Familial prostate cancer.