While the database Oncomine reports no differences or only slight differences in the gene expression levels of STIM1, STIM2, Orai1, Orai2, and Orai3, TRPM4 expression is reported to be elevated in 8 out of 9 studies that compared its expression in cancer tissue samples versus normal or benign prostate tissue (Table 1). The gene discussed is ORAI1; the disease is cancer.