For STIM1, 2 of 16 studies [59, 67] showed slightly elevated levels of STIM1 gene expression in prostate cancer tissue, while 2 out of 5 studies [53, 54] reported elevated or slightly elevated gene expression levels for STIM2. These results suggest that some SOCE components may be dysregulated in prostate cancer. Here, STIM2 is linked to Familial prostate cancer.