STIM1 and Familial prostate cancer: For STIM1, 2 of 16 studies [59, 67] showed slightly elevated levels of STIM1 gene expression in prostate cancer tissue, while 2 out of 5 studies [53, 54] reported elevated or slightly elevated gene expression levels for STIM2. These results suggest that some SOCE components may be dysregulated in prostate cancer.