Serial intravascular ultrasonography (IVUS), an invasive method for the detection of CAD events, revealed that PCSK9 inhibitor exerted favorable effects against the progression of coronary atherosclerosis.2 Moreover, coronary computed tomographic angiography (CCTA) has recently emerged as an accurate non-invasive method for the detection of coronary atherosclerosis and exclusion of obstructive CAD.3 Unlike IVUS, CCTA is a non-invasive method that is easy to use in outpatient clinics. The gene discussed is PCSK9; the disease is coronary atherosclerosis.