These findings suggested that erinacine A-enriched H. erinaceus mycelia may be a promising agent for stroke injury as these have the ability to decrease neuronal apoptosis and reduce stroke cavity size in the rat brains by targeting iNOS/reactive nitrogen species (RNS) and p38 mitogen-activated protein kinase (MAPK)/CCAAT enhancer-binding protein homologous protein (CHOP) pathways. The gene discussed is NOS2; the disease is Stroke.