The relationship between FKBP5 methylation, a surrogate marker for presumed chronic cortisol exposure, glycemic control in T2DM, and cardiovascular disease (CVD) risk, is notably indicated by the medium to large effect size of the association between intron 2% DNAm with HbA1c and WC, and the medium effect size of the relationship with LDL cholesterol. This evidence concerns the gene FKBP5 and type 2 diabetes mellitus.