In the recent, massive CANTOS trial of 10,061 patients with previous myocardial infarction and C-reactive protein (CRP) > 2 mg/l, selective blockade of IL-1β with the monoclonal antibody canakinumab conferred protection against recurrent cardiovascular events (74); secondary analyses of results determined that more robust reductions in CRP after the first dose of canakinumab predicted greater clinical benefits, again confirming the role of IL-1 as driving force of cardiac and systemic inflammation (74–80). This evidence concerns the gene IL1B and myocardial infarction.