The disseminated nature of the neoplasia developed in C91/III-injected mice was paralleled by a substantial alteration in the secretory profile of these cells, mainly characterized by the significant increase of several soluble factors, most of which equipped with a direct (IL-1α, IL-6, TNFα) or indirect (mainly chemokines) pro-inflammatory activity (Figure 4). The gene discussed is TNF; the disease is neoplasm.