The effects of phenotype (severe-obese vs overweight with the same genotype), studied in the comparison severe-obese-LH: 0–2 vs overweight-LH: 0–2, are evident in most (71%) of the well-known (blood pressure, heart rate, waist to hip, triglycerides, and HDL-C) and novel CVD risk factors [inflammation markers (CRP, leukocytes, and MCP-1), fibrinogen and glucose homeostasis (insulin resistance and glycated hemoglobin)], but not in LTL. This evidence concerns the gene CRP and Insulin resistance.