Moreover classic CVD risk factors (blood pressure, heart rate, waist to hip, triglycerides, and HDL-C) and novel CVD/T2D risk factors [inflammation markers (CRP, leukocytes, and MCP-1), fibrinogen, and glucose homeostasis (insulin resistance and glycated hemoglobin)] were significant altered in severe-obese vs overweight with the same genotype (LH: 0–2) point to the fact that obesity represents a harmful condition that leads to worsen the CVD risk factor profile. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.